Nov 21, 2014 the microemulsion definition provided by danielson and lindman in 1981 will be used as the point of reference. Definition and history one of the best definitions of microemulsions is from danielsson and lindman 1 a microemulsion is a system of water, oil and an amphiphile which is a single optically isotropic and thermodynamically stable liquid solution. A microemulsion is an emulsion which forms spontaneously, without mechanical action, from a mixture of two liquid phases under certain conditions surfactant concentration, salt content. Terminology, differences, and similarities article pdf available in soft matter 86. Schulman and coworker 1959 subsequently coined the term microemulsion. Microemulsion is an isotropic mixture of oil, surfactant, cosurfactant and drug. Microemulsions microemulsions are thermodynamically stable, optically transparent, isotropic dispersions of aqueous and hydrocarbon liquids stabilized by an interfacial film of surfactant molecules microemulsions show diverse structural organizations due to wide range of surfactant concentrations, wateroil ratios, temperature etc. Issa katime, jesus arellano, eduardo mendizabal, jorge flores subject. Mandal baroda college of pharmacy, vadodara, india. This poor solubility may cause poor dissolution and unpredicted. A thin fe 3 o 4 layer was produced on the iron nanoparticles using slow, controlled oxidation at room temperature.
Microemulsion synthesis of iron coreiron oxide shell. This product provides three unique electron donor materials which produce a beneficial and sequential, stagedrelease of each individual electron donor component. Dec 28, 2015 microemulsion is an isotropic mixture of oil, surfactant, cosurfactant and drug. Screening of safflower oil microemulsion for enhancing. A comparative study of nonlipid nanoemulsion of propofol. The aqueous phase may contain salts andor other ingredients, and the oil may actually be a complex mixture of different hydrocarbons and. Microemulsions microemulsions are thermodynamically stable, optically transparent, isotropic dispersions of aqueous and hydrocarbon liquids stabilized by an interfacial film. Ionic liquid microemulsionmediated in situ thermosynthesis of polyionic. However, the situation of petroleum industries in many countries needs much concern in improving the oil recovery technique. This product provides three unique electron donor materials which produce a. Design and characterization of microemulsion systems for naproxen. In some respects, microemulsions can be considered as smallscale.
With the first approach, the development methodology becomes one of blending three components where one of the components is the emulsifier of interest, another is the continuous phase solvent. At this position, i worked until 1209 2012 and was selected as professor of pharmaceutics in selection board held on 2808 2012 with effect from 19122010. Naproxen nap, figure 1 is a nonsteroidal antiinflammatory drug derived of propionic acid used widely as analgesic, antipyretic and for symptoms relief of dysmenorrheal pain. Nasal route for the delivery of some drugs offers an alternative in the pharmaceutical industry. Microemulsion article about microemulsion by the free. Its low solubility leads to low dissolution rate and thus poor therapeutic efficacy. Microemulsion polymerization is a complex heterogeneous process where transport of monomers, free radicals and other species such as chain transfer agent, cosurfactant and inhibitors between the aqueous and organic phases, takes place. Macroemulsions comprise large droplets and thus are unstable in the sense that the droplets sediment or float, depending on the densities of the dispersed phase and dispersion medium. Hence administering glimepiride by oral route appears as a formidable challenge due to its poor absorption pattern and. Chemical method, especially microemulsion flooding, plays an important role in enhanced oil recovery technique due to its ability to reduce interfacial tension between.
Microemulsion definition of microemulsion by merriamwebster. Progress in microemulsion characterization sciencedirect. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. To disperse two immiscible liquids, one needs a third component, namely, the emulsi. Isbn 9789535102472, pdf isbn 9789535149712, published 2012 0316. Nanoemulsion based1008 is a surfactantstabilized soybean oilinwater nanoemulsion adjuvant containing influenza antigen incorporated into the nanoemulsion by simple mixing. Iron magnetic nanoparticles were synthesized under an inert atmosphere via the reaction between fecl 3 and nabh 4 in droplets of water in a microemulsion consisting of octane with cetyl trimethylammonium bromide and butanol as surfactants. Citescore values are based on citation counts in a given year e. Ionic liquid microemulsion mediated in situ thermosynthesis of polyionic liquids and their adsorption properties for znii. Recent asian journal of pharmaceutical sciences articles.
The objective of the study was to optimize the proportion of different components for formulating oil in water microemulsion formulation meant for simultaneous transdermal delivery of. They described these systems as optically isotropic, transparent oil and water dispersions of droplets whose diameters were somewhat greater than swollen micelles. Definition and history one of the best definitions of microemulsions is from danielsson and lindman 1 a microemulsion is a system of water, oil and an amphiphile which is a. Feb 07, 20 naproxen nap, figure 1 is a nonsteroidal antiinflammatory drug derived of propionic acid used widely as analgesic, antipyretic and for symptoms relief of dysmenorrheal pain.
Formulation and evaluation of microemulsion based topical. The aim of the present study was to design novel ow microemulsion of glimepiride and to study its. Nanostructured microemulsion phase behavior using aot or extended surfactant combined with a cationic hydrotrope 54 ene oxide sulfate is also indicated. Formulation and evaluation of microemulsion based hydrogel for topical delivery article pdf available in international journal of pharmaceutical investigation 23. Depending on the structure of the surfactant and the presence or absence of cosurfactant, an oilinwater system winsor type i, a waterinoil system. First isolated from the roots of white hellebore veratrum glandiflorum, the extract of which contains transrsv of a purity range of 10% to 99%, rsv is mainly found in daily foods, such as grapes fresh grape skin contains about 50100 g of rsv, red wine 1. Thesis formulation and investigation of gelemulsions. Abstract nanoemulsion ne is defined as an ow or wo emulsion producing a transparent product that has a droplet size from 20200nm and does not have the tendency to coalesce. Different synthesis techniques have been developed to obtain highly pure monodomain barium ferrite particles for the application as permanent magnets. Cationic microemulsion polymerization of alkyl acrylates. Nonsmall cell lung carcinoma nsclc, accounting for 80% of all lung cancers, is a lethal lung disorder because of uncontrollable tumor cell growth and consequent metastasis, invasion of adjacent tissue, and loss of lung function.
Department of quality assurance bharati vidyapeeth college of pharmacy, kolhapur. The aqueous phase may contain salts andor other ingredients, and. A potential novel drug delivery system jaspreet kaur saini 1, ujjwal nautiyal 1, senthil kumar m 1, devendra singh 2, firoz anwar 3 1department of pharmaceutics, himachal institute of. Macroemulsions comprise large droplets and thus are unstable in the sense that the droplets. At this position, i worked until 1209 2012 and was selected as professor of pharmaceutics in selection board held on 2808 2012. The trend of growing interest in alternative source of energy focuses on renewable products worldwide. Nanostructured microemulsion phase behavior using aot or. Microemulsion transdermal formulation for simultaneous. Pdf on mar 16, 2012, anna zielinskajurek and others published nanoparticles preparation using microemulsion systems find, read and cite all the research you need on researchgate. Emulsion in which the particles of the dispersed phase have diameters from approximately 1 to 100. It does not require an input of energy into the system to form. Physicalchemical characterisation, acta pharmaceutica hungarica 78 2008 1121 if.
A microemulsion is an emulsion which forms spontaneously, without mechanical action, from a mixture of two liquid phases under certain conditions surfactant concentration, salt content, temperature. Upon mild agitation followed by dilution in aqueous media, such as gastrointestinal gi fluids, the systems can. A platform for improving dissolution rate of poorly water soluble drug surjyanarayan mandal and snigdha. This poor solubility may cause poor dissolution and unpredicted bioavailability kiran et al. Soni, rekha mishra institute of pharmacy, bundelkhand university, jhansi, india. The main potentialities of resveratrol for drug delivery systems. Microemulsion definition is an emulsion in which the dispersed phase is in the form of very small droplets usually produced and maintained with the aid of surfactants and having diameters of from 50 to 500 angstroms. Preparation and characterization of functional compounds. Microemulsionbased synergistic dualdrug codelivery system. Design and characterization of microemulsion systems for.
Phase behavior of microemulsion reflected by the pseudoternary phase diagram is a key parameter of the application of pdilms. Microemulsion method for synthesis of magnetic oxide nanoparticles by a. The aim of the present research work was to formulate hydrogel thickened microemulsion with good stability, powerful permeation ability and suitable viscosity for the topical menthol as oily phase, solvent for the lornoxicam, power. A microemulsion preparation of nanoparticles of europium in. Tween 20, 40, 60, and 80 were used separately as surfactant with methanol, ethanol, 1. Upon mild agitation followed by dilution in aqueous media, such as gastrointestinal gi fluids, the systems can form fine oil in water ow microemulsions which usually have a droplet size less than 100 nm.
Department of pharmaceutics appasaheb birnale college of pharmacy, sangli 2. Basic aspects of microemulsion microemulsion are fluid. A potential novel drug delivery system jaspreet kaur saini 1, ujjwal nautiyal 1, senthil kumar m 1, devendra singh 2, firoz anwar 3 1department of pharmaceutics, himachal institute of pharmacy, paonta sahib, himachal pradesh, india. The term microemulsion first entered the scientific vernacular in 1959, through the work of jack h. Microemulsion polymerization is a complex heterogeneous process where transport of monomers, free radicals and other species such as chain transfer agent, cosurfactant and inhibitors between the. Microemulsions are clear, stable, isotropic liquid mixtures of oil, water and surfactant, frequently in combination with a cosurfactant. Screening of safflower oil microemulsion for enhancing bioavailability of lovastatin sujit arun desai1rishikesh ajit mohite,2, ashok a.
Microemulsions an introduction to properties and applications. To investigate the effect of various surfactants and cosurfactants, and their ratio on microemulsions prepared with isopropyl palmitate ipp methods. In contrast to a simple emulsion formed under shear, a microemulsion is a minimum energy state. Characterization of microemulsions prepared using isopropyl. Basic aspects of microemulsion microemulsion are fluid, transparent, thermodynamically stable oil and water system and stabilized by a surfactant usually in conjunction with cosurfactant. To investigate the effect of various surfactants and cosurfactants, and their ratio on microemulsions prepared with isopropyl. This chapter gives the details of experimental work done. Pdf formulation and evaluation of microemulsionbased. Microemulsion definition is an emulsion in which the dispersed phase is in the form of very small droplets usually produced and maintained with the aid of surfactants and having diameters of from 50. The microemulsion concept was introduced as early as 1940s by hoar and schulman who generated a clear singlephase solution by titrating a milky emulsion with hexanol. Different synthesis techniques have been developed to obtain highly. The aim of the present research work was to formulate hydrogel thickened microemulsion with good.
549 2 1192 1557 1186 1231 353 1305 1248 1254 278 373 575 225 1203 1266 297 774 999 310 999 1123 217 939 539 1459 72 1472 773 43 1222 1112 14 220 165 1032 1293 1190